SoHo is known for their various boutique hotels. On the outerskirts of the neighborhood, several larger chains have opened over the past few years as well. Hotels in SoHo are normally less expensive than tourist-heavy Times Square.
| Hotel Brand | Address | Type | Phone |
| Azure Hotel | 120 Lafayette | Boutique Hotel | (212) 925-4378 |
| Courtyard SoHo | 181 Varick | Chain Hotel | (212) 414-8282 |
| Crosby Street Hotel | 79 Crosby | Boutique Hotel | (212) 226-6400 |
| Four Points Sheraton | 66 Charlton | Chain Hotel | (212) 229-9988 |
| Hampton Inn SoHo | 54 Watts | Chain Hotel | (212) 226-6288 |
| Hotel Hugo | 525 Greenwich | Boutique Hotel | (212) 608-4848 |
| James Hotel | 27 Grand | Boutique Hotel | (212) 465-2000 |
| Mercer Hotel | 147 Mercer | Boutique Hotel | (212) 966-6060 |
| NoMo SoHo | 9 Crosby | Boutique Hotel | (212) 389-1000 |
| Sixty Thompson | 60 Thompson | Boutique Hotel | (212) 431-0400 |
| SoHo Grand | 310 West Broadway | Boutique Hotel | (212) 965-3000 |
| The Broome Hotel | 431 Broome | Boutique Hotel | (212) 431-2929 |
| The Nolitan Hotel | 30 Kenmare | Boutique Hotel | (212) 925-2555 |
| Trump SoHo | 246 Spring | Boutique Hotel | (212) 842-5500 |
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